My story and recovery from T2 diabetes 10.2% hba1c to 5.3% hba1c.
Reversing T2 in clinical practise, the experience and the evidence.
Why does Swiss Re want to fix metabolic health?
All clips used in the presentations and the full conversation.
- Mental Health -
All clips used in the presentations and the full conversation.
Francesco Branca, WHO director Nutrition and Food Security.
Dietary Guidelines. "They have been designed to look at prevention of weight gain - the treatment of obesity is a different issue".
Dietary Guidelines were first introduced in 1976 with America leading the way.
By 2014 30% of Americans were obese.
By 2023 it is more than 42% including 20% of adolescents and children.
92% of Americans no longer meet the definition of healthy.
"And of course we also acknowledge that diets very high in carbohydrate could be very poor in diversity with very low nutritional value and with little macronutrients"
"It is true that when we do our systematic reviews it has to be based on individuals that are healthy"
(F. Branca)
"Of which there are fewer and fewer" (J. Schoonbee)
"Obesity is a disease per se"
“We look at studies that only look at healthy people by design “
*
“Services for obesity and diabetes are not sufficient and also there is no demand for those services”
*
“Health systems do not consider obesity as a priority, most health systems don’t have that, they think
it is a personal choice, so primary healthcare physicians are left on their own“
*
“We need to do more about helping primary physicians to be
very practical about their recommendations to patients
in the context of obesity
and type 2 diabetes, this is work which is going on”.
“I do think in populations in low-income countries, where you see the high proportion of fat, the quality of fat is extremely poor – we are talking about, for example poor neighbourhoods in Pakistan where they have a large consumption of industrial trans fats “
*
(Amanda – in discussion with Branca directly) - THIS is what drives the WHO stance on fats, not the consumption of real food.
*
“We are accepting that, there could be a flexibility up to say 40% “
“We need to be looking a food-based guidelines” (Amanda -an egg is 62% fat).
“The next step has to be about food groups… The issue of highly processed food is the kind of element we need to consider”
“Animal sourced foods are definitely an important component. Our new guidelines on complementary foods are basically stating that there should be a daily portion for children below the age of two years’ “
"Definitely eggs, fish, dairy products, for example insects in other countries, not in the western culture" (Amanda -reflecting the global security issue in developing nations where lack of animal-based proteins is known to cause stunting in infants).
“I acknowledge the fact that we actually haven’t recognised mental health as an outcome.“
"I have become convinced very strongly that the most powerful way to change brain health is through food because that is where brain chemicals come from in the first place".
"The more refined carbohydrate you eat, the higher your blood sugar levels will be. But the higher your insulin levels will be. So, high blood sugar, high brain insulin. Overtime paradoxically the higher the blood insulin, the lower brain insulin".
A ketogenic diet is a godsend for
the insulin resistant energy deficient brain.
What does a brain healthy diet achieve?
-This element omitted from the presentation due to time constraints.
Amanda Atkins.
Slide 6 – Effects of a low-carbohydrate diet on glycemic control in outpatients with severe type 2 diabetes.
Haimoto H, Sasakabe T, Wakai K, Umegaki H. PMID: 19419563
https://pubmed.ncbi.nlm.nih.gov/19419563/
Dr David Unwin.
Slide 2 – Estimating life years lost to diabetes: outcomes from analysis of National Diabetes Audit and Office of National Statistics data.
A.H. Heald, M. Stedman, M. Davies, M. Livingston, R. Alshames, M. Lunt, G. Rayman, R. Gadsby.
Cardiovascular Endocrinology & Metabolism. 2020; 9(4):183-185.
https://pubmed.ncbi.nlm.nih.gov/33225235/
Slide 5 – Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes.
Riddle MC, Cefalu WT, Evans PH, Gerstein HC, Nauck MA, Oh WK, Rothberg AE, le Roux CW, Rubino F, Schauer P, Taylor R, Twenefour D. Diabetes Care 2021
https://pubmed.ncbi.nlm.nih.gov/34462270/
Slide 10 - Does a Ketogenic Diet Have a Place Within Diabetes Clinical Practice? Review of Current Evidence and Controversies.
C.H. Firman, D.D. Mellor, D. Unwin and A. Brown (2023). Diabetes Therapy.
https://link.springer.com/article/10.1007/s13300-023-01492-4
Slide 13 - Effect of low-fat diet interventions versus other diet interventions on long-term weight change in adults: a systematic review and meta-analysis.
Tobias DK, Chen M, Manson JE, Ludwig DS, Willett W, Hu FB.
The Lancet Diabetes & Endocrinology. 2015;3(12):968-79.
https://pubmed.ncbi.nlm.nih.gov/26527511/
Slide 15 - What predicts drug-free type 2 diabetes remission? Insights from an 8-year general practice service evaluation of a lower carbohydrate diet with weight loss.
D. Unwin, C. Delon, J. Unwin, S. Tobin, R. Taylor.
BMJ Nutrition, Prevention and Health, 2023; 6(1):46-55.
https://pubmed.ncbi.nlm.nih.gov/37559961/
Slide 16 - Renal function in patients following a low carbohydrate diet for type 2 diabetes: a review of the literature and analysis of routine clinical data from a primary care service over 7 years. D. Unwin, J. Unwin, D. Crocombe, C. Delon, N. Guess, C. Wong.
Current Opinion in Endocrinology, Diabetes and Obesity. 2021.
https://pubmed.ncbi.nlm.nih.gov/34468402/
Slide 17 - Association between changes in carbohydrate intake and long term weight changes: prospective cohort study.
Wan Y, Tobias DK, Dennis KK, Guasch-Ferré M, Sun Q, Rimm EB, et al.
BMJ. 2022; 35(1):165-178.
https://pubmed.ncbi.nlm.nih.gov/37758268/
Slide 18 - Dietary strategies for remission of type 2 diabetes: A narrative review.
Brown A, McArdle P, Taplin J, Unwin D, Unwin J, Deakin T, Wheatley S, Murdoch C, Malhotra A, Duane M. Journal of Human Nutrition and Dietetics. 2021; n/a(n/a).
https://pubmed.ncbi.nlm.nih.gov/34323335/
Slide 19 - Effects of carbohydrate-restricted diets on low-density lipoprotein cholesterol levels in overweight and obese adults: a systematic review and meta-analysis.
Gjuladin-Hellon T, Davies IG, Penson P, Amiri Baghbadorani R. Nutr Rev. 2019.
https://pubmed.ncbi.nlm.nih.gov/30544168/
Slide 20 - Dose-dependent effect of carbohydrate restriction for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized controlled trials. A. Jayedi, S. Zeraattalab-Motlagh, B. Jabbarzadeh, Y. Hosseini, A. T. Jibril, H. Shahinfar, A. Mirrafiei, F. Hosseini, S. Shab-Bidar.
Am J Clin Nutr. 2022. Social Determinants of Health Research Center, Semnan University, Iran;
https://pubmed.ncbi.nlm.nih.gov/35537861/
Slide 21 - 5. Facilitating Behavior Change and Well-being to Improve Health Outcomes: Standards of Medical Care in Diabetes-2022.
Committee ADAPP. Diabetes Care. 2022;45(Supplement_1):S60-S82.
https://pubmed.ncbi.nlm.nih.gov/34964866/
Slide 28 - Metrics Beyond Hemoglobin A1C in Diabetes Management: Time in Range, Hypoglycemia, and Other Parameters.
L. Alarcon-Casas Wright, Irl B. Hirsch. Diabetes Technol Ther, 2017. 19(S2): p. S16-S26.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444503/
Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo.
Nieuwdorp, M., et al., Diabetes, 2006. 55(2): p. 480-486.
https://pubmed.ncbi.nlm.nih.gov/16443784/
Slide 31 (PDF) - Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.
Lim EL1, Hollingsworth KG, Taylor R. Diabetologia. 2011 Oct;54(10):2506-14.
https://www.nhsggc.org.uk/media/259813/david-unwin-type-2-diabetes.pdf
Slide 37 - Adapting diabetes medication for low carbohydrate management of type 2 diabetes: a practical guide.
Murdoch C, Unwin D, Cavan D., Cucuzella Patel M.
British Journal of General Practice. 2019 Jul; 69(684): 360–361.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592353/
Dr John Schoonbee.
Slide 1 - Financial information https://www.swissre.com/investors/financial-information.html
Slide 5 - The future of life expectancy. May 2023, Swiss Re Institute.
Can they use the Freshwell app as a sample diet of what is being suggested?
Yes, it is free to download.
Dr David Oliver will be like exhibiting the Freshwell Low Carb app at our conference this year, having conceived of it after coming to a previous PHC conference.
What about fibre and gut biome, lentils etc, provide fibre which is important for the gut biome?
A well formulated low carb diet has sufficient fibre because of the green vegs and nuts, please read this paper from the British Medical Journal:
‘a well-planned LCHF meal plan can be considered micronutrient replete. This is an important finding for health professionals, consumers and critics of LCHF nutrition, as it dispels the myth that these diets are suboptimal in their micronutrient supply.
As with any diet, for optimal nutrient achievement, meals need to be well formulated.’
What about diabetics with renal failure? There are a number of relevant papers on this.
‘In patients with T2D, unrestricted dietary protein intake was not associated with an increased hazard of renal function deterioration. Therefore, substituting carbohydrates with dietary protein is not contraindicated as a part of T2D management, although it may have a positive effect on body weight while minimizing loss of muscle mass.’
Is Cronometer really free?
All of the features and functionality of the Cronometer basic account, which is available to everyone free of charge.
Don’t have an account?
What about carb craving and the Keto flu (patients experience
this even on a low carb diet)?
Keto flu is the body adjusting to burning fat as a fuel instead of carbohydrates. In our practice it is rarely a problem being transient and improved by increasing oral fluids, salt and magnesium temporarily.
In the study you presented, Dr. Unwin, a small % of patients had worsening of their Creatinine. Do you know why did this happen? Where they take off the low carb diet?
Please take the time to read our open access paper (6) The point is after 30 months with T2 diabetes all the patients would be expected to have lost some renal function so in that context the average significant improvements were astonishing Not one of our patients has ever had to come off the lower carb diet because of this.
What about diabetics with renal failure?
There are a number of relevant papers on this (2-4) (5)
In patients with T2D, unrestricted dietary protein intake was not associated with an increased hazard of renal function deterioration. Therefore, substituting carbohydrates with dietary protein is not contraindicated as a part of T2D management, although it may have a positive effect on body weight while minimizing loss of muscle mass.
The Nutrition Network is an online, accredited education, connection, and learning platform founded by The Noakes Foundation in partnership with an esteemed team of doctors and scientists. The platform has been designed for healthcare practitioners across all disciplines, covering the latest science and research in the field of Therapeutic Carbohydrate Restriction.
Public Health Collaboration is a UK registered charity (1171887 / SC052248) dedicated to improving the health of the public and saving the NHS money at the same time. We do this through various projects, but at the heart of it all is our passion to help people become healthier and happier.
The Freshwell Low Carb Project is an initiative set up by Dr David Oliver and Dr Kim Andrews at the Freshwell Health Centre, Essex, UK, to encourage the members of its community to live a Real Food Low Carb lifestyle, so they may be as healthy as possible.
Establishing a Standard of Care (SoC) for carbohydrate restriction interventions through maintenance of Clinical Guidelines for practitioners of carbohydrate reduction and establishing an online communication forum between practitioners on all subjects related to metabolic health.
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